The course will provide an overview of pharmacological concepts for scientists. The focus is on pharmacokinetic (PK)/ pharmacodynamic (PD) models as an area of expertise for scientists rather than health care professionals. Students will learn basic pharmacological concepts and terminology that allow them to understand the biological mechanisms that are reflected in standard PK/PD models. We will cover PK models that reflect different administration routes (e.g. intraveneous, oral), single or repetitive dosing and drug distribution in different body compartments. We will also cover techniques to analyze PK data from clinical studies. Students will use online modelling tools to practice their skills. Student seminars will cover main therapeutic areas (e.g. drugs acting on peripheral nervous system, central nervous system, respiratory tract etc).
Grading will be based on a 15 min presentation with questions (50%) and an oral exam at the end of the semester (50%). Simulation exercises and ungraded tests during the course will be a starting point for the oral exam.
Textbooks: Hitner, Pharmacology: An Introduction, McGraw/Hill (older edition free to borrow here https://archive.org/details/pharmacologyintr0000hitn_u0p1)
Katzung/Vanderah, Basic & Clinical Pharmacology, McGraw/Hill (older edition free to borrow here
https://archive.org/details/BasicAndClinicalPharmacologyKatzung13EKaugipUnitedVRG)Rosenbaum, BASIC PHARMACOKINETICS AND PHARMACODYNAMICS: An Integrated Textbook and Computer Simulations, Wiley
(older edition can be downloaded here https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwji5LTU0YSCAxUMRvEDHTYyApQQFnoECBIQAQ&url=https%3A%2F%2Ftuaulavirtual.educatic.unam.mx%2Fpluginfile.php%2F2294977%2Fmod_folder%2Fcontent%2F0%2FBiofarmacia%2520y%2520Farmacocin%25C3%25A9tica%2FRosenbaum%2520-%2520Basic%2520Pharmacokinetics%2520and%2520Pharmacodynamics.pdf%3Fforcedownload%3D1&usg=AOvVaw2_u_unohysccd0F3fq53ly&opi=89978449)- Dozent/in: Pia Abel-zur Wiesch genannt H